Selected publications

- Polari L, Alam CM, Nyström JH, Heikkilä T, Tayyab M, Baghestani S, Toivola DM. Keratin intermediate filaments in the colon: guardians of epithelial homeostasis. 2020 International Journal of Biochemistry & Cell Biology 129: 105878.

- Alam CM, Baghestani S, Toivola DM. Intermediate Filament Keratins in The Exocrine Pancreas. 2020 Pancreapedia.

- Polari L, Anttila S, Helenius T, Wiklund A, Linnanen T, Toivola D, Määttä J. Novel Selective Estrogen Receptor Modulator Ameliorates Murine Colitis. 2019 Int J Mol Sci. 20(12), 3007.

- Pulli I, Löf C, Blom T, Asgharag MY, Lassila T.Bäck N, Lin KL, Nyström JH, Kemppainen K, Toivola DM, Dufourd E, Sanz A, Cooper HM, Parys JB, Törnquistag K. Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells. 2019 Biochim Biophys Acta Mol Cell Res. 1866(9), 1475-1486.

- Alam CM, Silvander JSG, Helenius TO, Toivola DM. Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes. 2018 Acta Physiol (Oxf). e13085. doi: 10.1111/apha.13085. [PubMed]

- Silvander JSG, Kvarnström SM, Kumari-Ilieva A, Shrestha A, Alam C, Toivola DM. Keratins regulate beta-cell mitochondrial morphology, motility and homeostasis. 2017 FASEB J. 31: 4578-4587. [PubMed]

- Lähdeniemi IAK, Misiorek JO, Antila CJM, Landor SK, Stenvall CA, Fortelius LE, Bergström LK, Sahlgren C, Toivola DM. Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell Death Differ. May 5. doi: 10.1038/cdd.2017.28. [Epub ahead of print], 2017.

- Helenius TO, Antman CA, Asghar MN, Nyström JH, Toivola DM. Keratins Are Altered in Intestinal Disease-related Stress Responses. Cells. 2016 Sep 10;5(3). pii: E35. doi: 10.3390/cells5030035.

- Misiorek JO, Lähdeniemi IA, Nyström JH, Paramonov VM, Gullmets JA, Saarento H, Rivero-Muller A, Husöy T, Taimen P, Toivola DM. Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. Carcinogenesis. 37(8):777-8, 2016.

- Asghar MN, Priyamvada S, Nyström JH, Anbazhagan AN, Dudeja PK, Toivola DM. Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon. Am J Physiol Gastrointest Liver Physiol. 310(11):G1147-54, 2016.

- Desai D, Prabhakar N, Mamaeva V, Karaman DS, Lähdeniemi IA, Sahlgren C, Rosenholm JM, Toivola DM. Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles. Int J Nanomedicine. 11:299-313, 2016.

- Toivola DM, Habtezion A, Misiorek JO, Zhang L, Nyström JH, Sharpe O, Robinson WH, Kwan R, Omary MB. Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice. FASEB J 29:5081-9,2015.

- Strnad P, Guldiken N, Helenius TO, Misiorek JO, Nyström JH, Lähdeniemi IA, Silvander JS, Kuscuoglu D, Toivola DM. Simple Epithelial Keratins. Methods Enzymol. 568:351-88, 2016. Review.

- Helenius, T.O., Misiorek, J.O., Nyström, J.H., Fortelius, L.E., Habtezion, A., Liao, J., Asghar, M.N., Zhang, H., Azhar, S., Omary, M.B., Toivola, D.M. Keratin 8 absence downregulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism. Mol. Biol. Cell 22. pii: mbc.E14-02-0736, 2015.

- Asghar, M.N., Silvander, J.S., Helenius, T.O., Lähdeniemi, I.A., Alam, C., Fortelius, LE, Holmsten RO, Toivola DM. The amount of keratins matters for stress protection of the colonic epithelium. PLoS One.10(5):e0127436, 2015.

- Toivola, D.M., Boor, P., Alam, C., Strnad, P. Keratins in health and disease. Curr. Opin. Cell Biol. 32:73-81, 2015.

- Asghar, M.N., Emani, R., Alam, C., Helenius, T.O., Grˆnroos, T.J, Sareila, O., Din, M.U., Holmdahl, R., Hänninen, A., Toivola, D.M. In vivo imaging of reactive oxygen and nitrogen species in murine colitis. Inflamm. Bowel Dis. 20:1435-47, 2014.

- Alam, C.A., Silvander, J.S.G., Daniel, E.N., Tao, G-Z, Kvarnström, S.M., Alam, P., Omary, M.B., Hänninen, A., Toivola, D.M. Keratin 8 modulates beta-cell stress and normoglycaemia. J.Cell Sci. In press, September 2013.

- Habtezion A, Toivola DM, Asghar MN, Kronmal GS, Brooks JD, Butcher EC, Omary MB. Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon. Proc Natl Acad Sci USA, 108:1445-1450, 2011.

- Toivola DM, Habtezion A, Strnad P, Omary MB. Intermediate filaments take the heat as stress proteins. Trends Cell Biol, 20:79-91, 2010.

- Toivola DM, Tao GZ, Habtezion A, Liao J, Omary MB. Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filament proteins. Trends Cell Biol, 15:608-617, 2005.

Complete list of publications

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