Selected publications

- Stenvall C-G, Nyström JH, Butler-Hallissey C, Jansson T, Heikkilä T, Adam SA, Foisner R, Goldman RF, Ridge RM, and Toivola DM: Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells. MBoC 2022, xxx, https://doi.org/10.1091/mbc.E20-06-0387

- Polari L, Voutilainen M, Kallajoki M, Toivola DM: Keratiinit suoliston epiteelisoluissa ja paksusuolisyövän analytiikassa. Duodecim 2022, 138(10), 889-896.

- Stenvall C-G, Tayyab, Mina A, Grönroos T, Ilomäki MA, Viiri K, Ridge KM, Polari L, Toivola DM: Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon. Cell Mol Life Sci 2022, 79:1–17. Available from: https://doi.org/10.1007/s00018-021-04081-5

- Alam CM, Baghestani S, Pajari A, Omary MB, Toivola DM: Keratin 7 is a constituent of the keratin network in mouse pancreatic islets and is upregulated in experimental diabetes. Int J Mol Sci 2021, 22

- Polari L, Alam CM, Nyström JH, Heikkilä T, Tayyab M, Baghestani S, Toivola DM. Keratin intermediate filaments in the colon: guardians of epithelial homeostasis. International Journal of Biochemistry & Cell Biology 2021, 129: 105878. https://doi.org/10.1016/j.biocel.2020.105878

- Alam CM, Baghestani S, Toivola DM. Intermediate Filament Keratins in The Exocrine Pancreas. Pancreapedia 2020. https://doi.org/10.3998/panc.2020.02

- Polari L, Anttila S, Helenius T, Wiklund A, Linnanen T, Toivola D, Määttä J. Novel Selective Estrogen Receptor Modulator Ameliorates Murine Colitis. Int J Mol Sci 2019, 20(12), 3007. https://doi.org/10.3390/ijms20123007

- Pulli I, Löf C, Blom T, Asgharag MY, Lassila T.Bäck N, Lin KL, Nyström JH, Kemppainen K, Toivola DM, Dufourd E, Sanz A, Cooper HM, Parys JB, Törnquistag K. Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells. Biochim Biophys Acta Mol Cell Res. 2019, 1866(9), 1475-1486. https://doi.org/10.1016/j.bbamcr.2019.06.006

- Alam CM, Silvander JSG, Helenius TO, Toivola DM. Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes. Acta Physiol (Oxf). 2018 e13085. doi: 10.1111/apha.13085. [PubMed]

- Silvander JSG, Kvarnström SM, Kumari-Ilieva A, Shrestha A, Alam C, Toivola DM. Keratins regulate beta-cell mitochondrial morphology, motility and homeostasis. FASEB J. 2017, 31: 4578-4587. [PubMed]

- Lähdeniemi IAK, Misiorek JO, Antila CJM, Landor SK, Stenvall CA, Fortelius LE, Bergström LK, Sahlgren C, Toivola DM. Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell Death Differ. 2017. doi: 10.1038/cdd.2017.28.

- Helenius TO, Antman CA, Asghar MN, Nyström JH, Toivola DM. Keratins Are Altered in Intestinal Disease-related Stress Responses. Cells. 2016, 5(3). pii: E35. doi: 10.3390/cells5030035.

- Misiorek JO, Lähdeniemi IA, Nyström JH, Paramonov VM, Gullmets JA, Saarento H, Rivero-Muller A, Husöy T, Taimen P, Toivola DM. Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. Carcinogenesis 2016, 37(8):777-8

- Asghar MN, Priyamvada S, Nyström JH, Anbazhagan AN, Dudeja PK, Toivola DM. Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon. Am J Physiol Gastrointest Liver Physiol. 2016, 310(11):G1147-54

- Desai D, Prabhakar N, Mamaeva V, Karaman DS, Lähdeniemi IA, Sahlgren C, Rosenholm JM, Toivola DM. Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles. Int J Nanomedicine. 2016, 11:299-313, 2.

- Toivola DM, Habtezion A, Misiorek JO, Zhang L, Nyström JH, Sharpe O, Robinson WH, Kwan R, Omary MB. Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice. FASEB J. 2015, 29:5081-9.

- Strnad P, Guldiken N, Helenius TO, Misiorek JO, Nyström JH, Lähdeniemi IA, Silvander JS, Kuscuoglu D, Toivola DM. Simple Epithelial Keratins. Methods Enzymol.2016 568:351-88.

- Helenius, TO, Misiorek, JO, Nyström, JH, Fortelius, LE, Habtezion, A, Liao, J., Asghar, MN, Zhang, H., Azhar, S., Omary, MB, Toivola, DM. Keratin 8 absence downregulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism. Mol. Biol. Cell 2015, 22. pii: mbc.E14-02-0736.

- Asghar, MN, Silvander, J.S., Helenius, T.O., Lähdeniemi, I.A., Alam, C., Fortelius, LE, Holmsten RO, Toivola DM. The amount of keratins matters for stress protection of the colonic epithelium. PLoS One.2015, 10(5):e0127436. Toivola, DM, Boor, P., Alam, C., Strnad, P. Keratins in health and disease. Curr. Opin. Cell Biol. 2015, 32:73-81.

- Asghar, MN, Emani, R., Alam, C., Helenius, TO, Grönroos, TJ, Sareila, O., Din, MU, Holmdahl, R., Hänninen, A., Toivola, DM. In vivo imaging of reactive oxygen and nitrogen species in murine colitis. Inflamm. Bowel Dis. 2014, 20:1435-47.

- Alam, C.A., Silvander, J.S.G., Daniel, E.N., Tao, G-Z, Kvarnström, S.M., Alam, P., Omary, M.B., Hänninen, A., Toivola, D.M. Keratin 8 modulates beta-cell stress and normoglycaemia. J.Cell Sci. 2013.

- Habtezion A, Toivola DM, Asghar MN, Kronmal GS, Brooks JD, Butcher EC, Omary MB. Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon. Proc Natl Acad Sci USA, 2011, 108:1445-1450.

- Toivola DM, Habtezion A, Strnad P, Omary MB. Intermediate filaments take the heat as stress proteins. Trends Cell Biol, 20:79-91, 2010.

Complete list of publications

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