Selected publications

- Ilomäki MA, Polari L, Stenvall C-G, Tayyab M, Kähärä K, Ridg KM, ToivolaDM: Defining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation. Am J Physiol Gastrointest Liver Physiol, 326, G67–G77. https://doi.org/10.1152/ajpgi.00140.2023

- Toivola DM, Polari L, Schwerd T, Schlegel N, Strnad P: The keratin-desmosome scaffold of internal epithelia in health and disease – The plot is thickening. Curr Op Cell Biol 2024, 86, 102282. https://doi.org/10.1016/j.ceb.2023.102282

- Bhowmik AA, Heikkilä TRH, Polari L, Virta J, Liljenbäck H, Moisio O, Li X-G, Viitanen R, Jalkanen S, Koffert J, Toivola DM, Roivainen A: Detection of Intestinal Inflammation by Vascular Adhesion Protein-1-Targeted [ 68 Ga]Ga-DOTA-Siglec-9 Positron Emission Tomography in Murine Models of Inflammatory Bowel Disease. Mol Imaging Biol 2023. https://doi.org/10.1007/s11307-023-01885-8

- Tenhami M, Polari L, Kujari H, Löyttyniemi E, Toivola DM, Voutilainen M: Keratin 7 expression in different anatomical parts of colonic epithelium in inflammatory bowel diseases and its prognostic value: a 3‑year follow‑up study. Sci Rep 2023, 13, 11797. https://doi.org/10.1038/s41598-023-39066-w

- Polari L,Tenhami M, Anttila S, Helenius T, Kujari H, Kallajoki M, Voutilainen M, Toivola DM. Colonocyte keratin 7 is expressed de novo in inflammatory bowel diseases and associated with pathological changes and drug‑resistance. Sci Rep 2022, 12, 22213, https://doi.org/10.1038/s41598-022-26603-2

- Stenvall C-G, Nyström JH, Butler-Hallissey C, Jansson T, Heikkilä T, Adam SA, Foisner R, Goldman RF, Ridge RM, and Toivola DM: Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells. MBoC 2022, 33(13), https://doi.org/10.1091/mbc.E20-06-0387

- Polari L, Voutilainen M, Kallajoki M, Toivola DM: Keratiinit suoliston epiteelisoluissa ja paksusuolisyövän analytiikassa. Duodecim 2022, 138(10), 889-896.

- Stenvall C-G, Tayyab, Mina A, Grönroos T, Ilomäki MA, Viiri K, Ridge KM, Polari L, Toivola DM: Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon. Cell Mol Life Sci 2022, 79:1–17. Available from: https://doi.org/10.1007/s00018-021-04081-5

- Alam CM, Baghestani S, Pajari A, Omary MB, Toivola DM: Keratin 7 is a constituent of the keratin network in mouse pancreatic islets and is upregulated in experimental diabetes. Int J Mol Sci 2021, 22

- Polari L, Alam CM, Nyström JH, Heikkilä T, Tayyab M, Baghestani S, Toivola DM. Keratin intermediate filaments in the colon: guardians of epithelial homeostasis. International Journal of Biochemistry & Cell Biology 2021, 129: 105878. https://doi.org/10.1016/j.biocel.2020.105878

- Alam CM, Baghestani S, Toivola DM. Intermediate Filament Keratins in The Exocrine Pancreas. Pancreapedia 2020. https://doi.org/10.3998/panc.2020.02

- Polari L, Anttila S, Helenius T, Wiklund A, Linnanen T, Toivola D, Määttä J. Novel Selective Estrogen Receptor Modulator Ameliorates Murine Colitis. Int J Mol Sci 2019, 20(12), 3007. https://doi.org/10.3390/ijms20123007

- Alam CM, Silvander JSG, Helenius TO, Toivola DM. Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes. Acta Physiol (Oxf). 2018 e13085. doi: 10.1111/apha.13085. https://www.ncbi.nlm.nih.gov/pubmed/29719117

- Silvander JSG, Kvarnström SM, Kumari-Ilieva A, Shrestha A, Alam C, Toivola DM. Keratins regulate beta-cell mitochondrial morphology, motility and homeostasis. FASEB J. 2017, 31: 4578-4587. https://www.ncbi.nlm.nih.gov/pubmed/28666985

- Lähdeniemi IAK, Misiorek JO, Antila CJM, Landor SK, Stenvall CA, Fortelius LE, Bergström LK, Sahlgren C, Toivola DM. Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell Death Differ. 2017. doi: 10.1038/cdd.2017.28.

Complete list of publications

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